Abstract |
Primary adrenal diffuse large B-cell lymphoma (PA-DLBCL) is rare. We investigate 23 Japanese patients with PA-DLBCL to understand the clinicopathologic features and biological behavior of this disease. The 17 males and 6 females had a median age of 74 years (range: 40 to 86 y). Tumor cells harbored Epstein-Barr virus-encoded small RNA (EBER) in 9 (39%) samples, including samples from the 2 patients with methotrexate-associated B-cell lymphoproliferative disorder. Programmed cell death ligand 1 (PD-L1) expression was detected in tumor cells of 6 (26%) samples, including 1 EBER+ and 5 EBER- samples. Four (17%) patients exhibited an intravascular proliferating pattern, and all 4 patient samples showed positive staining for PD-L1 in tumor cells. Among those patients, 3 showed intravascular proliferating pattern accompanied by a diffuse extravascular proliferation of tumor cells, and 1 patient was diagnosed with intravascular large B-cell lymphoma. We divided the 23 patients into 3 groups: EBER+ (n=9, 39%), EBER-PD-L1+ (n=5, 22%), and EBER-PD-L1- (n=9, 39%). A comparison of the outcomes among the 3 groups showed significant differences in overall survival (P=0.034). The EBER+ group had the worst prognosis, and the EBER-PD-L1- group had the best prognosis. We also compared the outcomes among the 3 groups that received rituximab-containing chemotherapies. Both the overall survival and progression-free survival were significantly different among these groups (P<0.001 and P=0.002, respectively). In conclusion, we evaluated 3 types of PA-DLBCL and found that each had unique clinical, pathologic, and prognostic features. Our results suggested that immune senescence, iatrogenic immunodeficiency, and immune evasion contribute to the development of PA-DLBCL.
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Authors | Tasuku Kawano, Yuta Tsuyuki, Yuka Suzuki, Kazuyuki Shimada, Seiichi Kato, Taishi Takahara, Mayuko Mori, Masato Nakaguro, Ayako Sakakibara, Shigeo Nakamura, Akira Satou |
Journal | The American journal of surgical pathology
(Am J Surg Pathol)
Vol. 45
Issue 12
Pg. 1606-1615
(12 01 2021)
ISSN: 1532-0979 [Electronic] United States |
PMID | 34534136
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- B7-H1 Antigen
- Biomarkers, Tumor
- CD274 protein, human
- RNA, Viral
- Rituximab
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Topics |
- Adrenal Gland Neoplasms
(immunology, pathology, therapy, virology)
- Adrenalectomy
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- B7-H1 Antigen
(analysis)
- Biomarkers, Tumor
(analysis)
- Epstein-Barr Virus Infections
(immunology, pathology, therapy, virology)
- Female
- Herpesvirus 4, Human
(genetics)
- Humans
- Japan
- Lymphoma, Large B-Cell, Diffuse
(immunology, pathology, therapy, virology)
- Male
- Middle Aged
- Progression-Free Survival
- RNA, Viral
(genetics)
- Retrospective Studies
- Risk Factors
- Rituximab
(therapeutic use)
- Time Factors
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