Does the microbiota spectrum of prostate secretion affect the clinical status of patients with chronic bacterial prostatitis?

Abstract

OBJECTIVE:

To explore the influence of the microbiota of prostate secretion on the clinical status of patients with chronic bacterial prostatitis.

METHODS:

This was an observational, single-center, comparative study. We evaluated the survey cards of 230 outpatients aged 18-45 years with a history of prostatitis from 2012 to 2019. As a result, 170 outpatients were selected for the study. All patients underwent an assessment of symptoms using International Prostate Symptom Score-quality of life, National Institutes of Health-Chronic Prostatitis Symptom Index, International Index of Erectile Function, pain visual analog scale. A bacteriological study (after the Meares-Stamey test) of post-massage urine was carried out on an extended media set. The following parameters were determined in each patient: leukocyturia and bacteriuria, serum testosterone and total prostate-specific antigen levels. Uroflowmetry, transrectal prostate ultrasound with color duplex mapping and ejaculate analysis were also carried out.

RESULTS:

Aerobic-anaerobic bacterial associations were identified in all patients. Three comparison groups were identified depending on the microbiota's spectrum (in post-massage urine): aerobes prevailed in group 1 (n = 67), anaerobes prevailed in group 2 (n = 33), and the levels of aerobic and anaerobic bacteriuria were higher than ≥103  colony-forming units per mL in group 3 (n = 70). It was found that the severity of clinical symptoms (urination disorders, sexual dysfunction etc.) of chronic bacterial prostatitis, laboratory and instrumental changes (testosterone, prostate-specific antigen, prostate volume etc.) in groups 2 and 3 were significantly higher than in group 1.

CONCLUSION:

In patients with chronic bacterial prostatitis, a predominance of anaerobes or a combination of aerobes and anaerobes in a titer of ≥103  colony-forming units per mL in post-massage urine is associated with worse clinical status.

• Authors: Mikhail Kogan, Yulia Naboka, Akhmed Ferzauli, Khalid Ibishev, Irina Gudima, Ruslan Ismailov
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 28 Issue 12 Pg. 1254-1259 (Dec 2021) ISSN: 1442-2042 [Electronic] Australia
• PMID: 34528294 (Publication Type: Journal Article, Observational Study)
• Copyright: © 2021 The Japanese Urological Association.

Topics

• Chronic Disease
• Humans
• Male
• Microbiota
• Pelvic Pain
• Prostate (diagnostic imaging)
• Prostatitis
• Quality of Life