miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma.

Abstract

INTRODUCTION:

Glioma is the most aggressive and malignant type of tumors among primary intracranial tumors. miR-433-3p has been verified to be correlated with the formation and progression of many types of cancers.

METHODS:

In this study, the effects of miR-433-3p and AJUBA on the proliferation, migration, and invasion of glioma and the molecular mechanisms were investigated. We analyzed bioinformatics databases and conducted cell biology experiments to determine that compared with adjacent tissue and normal cells, the expression level of miR-433-3p in glioma tissue and cells was lower, while the expression level of AJUBA was higher. Overexpressing miR-433-3p could significantly inhibit the proliferation, migration, and invasion of glioma cells and promote cell apoptosis.

RESULTS:

In addition, after overexpressing miR-433-3p and AJUBA, it was found that overexpressing AJUBA could attenuate the inhibitory effect of overexpressing miR-433-3p on the proliferation, migration, and invasion of glioma cells, which suggested that miR-433-3p regulated the biological function of glioma by downregulating AJUBA expression.

CONCLUSION:

These results proved that miR-433-3p could target to inhibit the expression of AJUBA, thus inhibiting the biological function and malignant progression of glioma.

• Authors: Jing Zhang, Yihang Guo, Yanrong Ma, Lipeng Wang, Weiyuan Li, Manyu Zhang, Jiaming Zhao, Yueming Hu, Hongmei Yu, Guozhi Hu
• Journal: Neuroimmunomodulation (Neuroimmunomodulation) Vol. 29 Issue 1 Pg. 44-54 ( 2022) ISSN: 1423-0216 [Electronic] Switzerland
• PMID: 34518486 (Publication Type: Journal Article)
• Copyright: © 2021 S. Karger AG, Basel.

Chemical References

• AJUBA protein, human
• LIM Domain Proteins
• MIRN433 microRNA, human
• MicroRNAs

Topics

• Brain Neoplasms (genetics, metabolism, pathology)
• Cell Line, Tumor
• Cell Movement (physiology)
• Cell Proliferation (physiology)
• Glioma (genetics, metabolism, pathology)
• Humans
• LIM Domain Proteins (biosynthesis, genetics, metabolism)
• MicroRNAs (genetics, metabolism)