The significances and clinical implications of cholesterol components in human breast cancer.

Abstract

Breast cancer is one the most common malignancies and leading cause of cancer-related mortality in women. Recent studies suggested that hypercholesterolemia may be the potential modifiable risk factors for breast cancer. Cholesterol was well-known for its strong association with cardiovascular disease for long. Moreover, solid evidence has been provided by different studies to illustrate the correlation between lipid and incidence in multiple cancers. Although the conclusion remains controversial or sometimes contrary, which may be due to the multifactorial nature of the disease and the disparity of ethnic population, it is critical to elucidate the relationship between specific cholesterol components in certain population and the exact underlying mechanism of the lipid-associated signaling pathway in breast cancer. The implications of dysregulated lipoproteins as therapeutic targets or options for breast cancer provide novel strategies for us in combating with this malignant disease, which may be achieved by manipulating lipid levels with pharmacological compounds.

• Authors: Yanghui Wei, Yao Huang, Weiqin Yang, Qingnan Huang, Yong Chen, Kai Zeng, Juan Chen, Jiawei Chen
• Journal: Science progress (Sci Prog) 2021 Jul-Sep Vol. 104 Issue 3 Pg. 368504211028395 ISSN: 2047-7163 [Electronic] England
• PMID: 34510991 (Publication Type: Journal Article)

Chemical References

• Cholesterol

Topics

• Breast Neoplasms (drug therapy)
• Cardiovascular Diseases (epidemiology)
• Cholesterol (metabolism, therapeutic use)
• Female
• Humans
• Hypercholesterolemia (drug therapy, metabolism)
• Risk Factors