HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Sesamin promotes apoptosis and pyroptosis via autophagy to enhance antitumour effects on murine T-cell lymphoma.

Abstract
Sesamin is a lignan compound in plants that has various pharmacological effects, including reducing diabetes-associated injuries, regulating fatty acid and cholesterol metabolism, and exerting antiinflammatory and antitumour effects. Previous studies have reported that sesamin can inhibit the proliferation of several types of tumour cells and exert antitumour effects. However, the antitumour effect of sesamin on T-cell lymphoma is still unknown. In this study, we selected a T-cell lymphoma mouse model to investigate the mechanism of sesamin against T-cell lymphoma via programmed cell death in vivo and in vitro. We found that sesamin could significantly inhibit the growth of EL4 cells in a tumour-bearing mouse model. Sesamin markedly inhibited the proliferation of EL4 cells by inducing apoptosis, pyroptosis and autophagy. Autophagy occurred earlier than apoptosis and pyroptosis in EL4 cells after sesamin treatment. Blocking autophagy inhibited apoptosis and pyroptosis in EL4 cells after sesamin treatment. Taken together, these results suggested that sesamin promoted apoptosis and pyroptosis via autophagy to enhance antitumour effects on murine T-cell lymphoma. This study expands our knowledge of the pharmacological effects of sesamin on T-cell lymphoma, and provides a theoretical basis for the development of new antitumour drugs and treatments for T-cell lymphoma.
AuthorsZiyu Meng, Hui Liu, Jing Zhang, Zena Zheng, Ziwei Wang, Li Zhang, Zhenghu Jia, Yutong Sui
JournalJournal of pharmacological sciences (J Pharmacol Sci) Vol. 147 Issue 3 Pg. 260-270 (Nov 2021) ISSN: 1347-8648 [Electronic] Japan
PMID34507635 (Publication Type: Journal Article)
CopyrightCopyright © 2021 The Authors. Production and hosting by Elsevier B.V. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Dioxoles
  • Lignans
  • sesamin
Topics
  • Animals
  • Antineoplastic Agents
  • Apoptosis (drug effects)
  • Autophagy (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Dioxoles (pharmacology, therapeutic use)
  • Disease Models, Animal
  • Female
  • Lignans (pharmacology, therapeutic use)
  • Lymphoma, T-Cell (drug therapy, pathology)
  • Mice, Inbred BALB C
  • Phytotherapy
  • Pyroptosis (drug effects)
  • Stimulation, Chemical
  • Mice

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: