Sertoli Leydig Cell Tumour Initially Misdiagnosed as Polycystic Ovarian Syndrome and Congenital Adrenal Hyperplasia: A Case Report.

Abstract

Sertoli-Leydig cell tumor of the ovary is an unusual neoplasm that belongs to a group of sex cord-stromal tumors of the ovary and accounts for less than 0.5% of all primary ovarian neoplasms. They are often characterized by the presence of mass with androgen production and signs of virilization. Due to the substantially low incidence of Sertoli-Leydig cell tumors, information on clinical behavior, prognostic factors, and optimal management arelimited. Here in, we report a case of aprimary ovarian Sertoli-Leydig cell tumor in a 21-year-old student, previously diagnosed to have polycystic ovarian syndrome and subsequently congenital adrenal hyperplasia, who presented with a large abdominal mass and features of virilization along with elevated serum testosterone levels. Fertility sparing unilateral salpingo-oophorectomy was done and adjuvant chemotherapy was given after histopathology showed moderate to poorly differentiated Sertoli-Leydig cell tumor. Following surgery, her features of hyperandrogenism resolved and serum testosterone levels returned to normal.

• Authors: Pooja Paudyal, Geeta Gurung, Josie Baral, Nisha Kharel
• Journal: JNMA; journal of the Nepal Medical Association (JNMA J Nepal Med Assoc) Vol. 58 Issue 231 Pg. 923-926 (Nov 22 2020) ISSN: 1815-672X [Electronic] Nepal
• PMID: 34506429 (Publication Type: Case Reports, Journal Article)

Topics

• Adrenal Hyperplasia, Congenital
• Adult
• Diagnostic Errors
• Female
• Humans
• Male
• Ovarian Neoplasms (diagnosis)
• Polycystic Ovary Syndrome (complications, diagnosis)
• Sertoli-Leydig Cell Tumor (diagnosis, surgery)
• Sex Cord-Gonadal Stromal Tumors (diagnosis, surgery)
• Young Adult