Efficacy of a Topical Wound Agent Methanesulfonic Acid and Dimethylsulfoxide on In Vitro Biofilms.

Abstract

A topical desiccating wound agent containing methanesulfonic acid, dimethylsulfoxide and amorphous silica was evaluated in three in vitro models for its efficacy against biofilms produced by Pseudomonas aeruginosa (ATCC-15442) and Staphylococcus aureus (ATCC-6538). The in vitro biofilm models used were; the MBEC Assay®, Centre for Disease Control (CDC) Biofilm Reactor® and a Semi-solid biofilm model. A 30-s exposure of a topical wound desiccating agent was used in each model. A complete eradication of viable cells was demonstrated in all models for both strains (p < 0.0001). Imaging with scanning electron microscopy (SEM) was performed where possible. All three models demonstrated complete eradication of viable cells with a 30 s application of a topical wound desiccating agent.

• Authors: Saskia Schwarzer, Michael Radzieta, Slade O Jensen, Matthew Malone
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 22 Issue 17 (Aug 31 2021) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 34502378 (Publication Type: Journal Article)

Chemical References

• Mesylates
• methanesulfonic acid
• Dimethyl Sulfoxide

Topics

• Administration, Topical
• Biofilms (drug effects)
• Dimethyl Sulfoxide (metabolism, pharmacology)
• Mesylates (metabolism, pharmacology)
• Pseudomonas Infections (drug therapy)
• Pseudomonas aeruginosa (drug effects, pathogenicity)
• Staphylococcal Infections (drug therapy)
• Staphylococcus aureus (drug effects, pathogenicity)
• Wound Healing (drug effects)
• Wound Infection (drug therapy)