Spatial coefficient of variation of arterial spin labeling MRI for detecting hemodynamic disturbances measured with 15O-gas PET in patients with moyamoya disease.

Abstract

PURPOSE:

The aim of this study was to investigate whether the spatial coefficient of variation of arterial spin labeling (ASL-CoV) acquired in clinical settings can be used to estimate the hemodynamic disturbances measured with 15O-gas positron emission tomography (PET), especially an increased oxygen extraction fraction (OEF), in patients with moyamoya disease.

METHODS:

We evaluated 68 adult patients with moyamoya disease who underwent ASL (postlabeling delay (PLD) = 1525 ms and 2525 ms) and PET. Regional values were measured using the middle cerebral artery territorial atlas divided into proximal, middle, and distal regions based on the arterial transit time, and correlations of ASL-CoV with cerebral blood flow, cerebral blood volume, mean transit time, and OEF, as well as the relationship between increased OEF and ASL-CoV, were evaluated.

RESULTS:

Regardless of the choice of region and PLD, ASL-CoV was significantly correlated with PET-measured parameters, including OEF (|ρ|= 0.30-0.80, P < 0.001). Regions with an increased OEF showed a significantly higher ASL-CoV than regions with a nonincreased OEF (P ≤ 0.03) regardless of the choice of region and PLD. The accuracy of identification of an increased OEF was highest when using a PLD of 1525 ms and the middle region (area under the curve = 0.750; using a cutoff value of 31.27, sensitivity = 97.4%, specificity = 41.7%, negative predictive value = 92.6%, and positive predictive value = 67.9%).

CONCLUSION:

ASL-CoV may help identify patients with increased OEF.

• Authors: Shoko Hara, Yoji Tanaka, Motoki Inaji, Shihori Hayashi, Kenji Ishii, Tadashi Nariai, Taketoshi Maehara
• Journal: Neuroradiology (Neuroradiology) Vol. 64 Issue 4 Pg. 675-684 (Apr 2022) ISSN: 1432-1920 [Electronic] Germany
• PMID: 34499192 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Chemical References

• Spin Labels

Topics

• Adult
• Cerebrovascular Circulation
• Hemodynamics
• Humans
• Magnetic Resonance Imaging (methods)
• Moyamoya Disease (diagnostic imaging)
• Positron-Emission Tomography (methods)
• Spin Labels