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Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt (NSC-361456).

Abstract
The synthesis, chemical stability and anti-tumor activity of pyrazine diazohydroxide, sodium salt, a compound that has been selected for development to clinical trials, are described. The compound shows a half-life of about 100 minutes at pH 7.4 and is active against a number of experimental tumors.
AuthorsD C Baker, E S Hand, J Plowman, J B Rampal, A Safavy, R D Haugwitz, V L Narayanan
JournalAnti-cancer drug design (Anticancer Drug Des) Vol. 2 Issue 3 Pg. 297-309 (Dec 1987) ISSN: 0266-9536 [Print] United States
PMID3449093 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents
  • Azides
  • Pyrazines
  • Pyrimidines
  • pyrazine-2-diazohydroxide
  • 3-azidopyrimethamine
  • Pyrimethamine
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis, therapeutic use)
  • Azides (chemical synthesis, pharmacology)
  • Drug Evaluation, Preclinical
  • Drug Stability
  • Female
  • Half-Life
  • Male
  • Mice
  • Mice, Inbred Strains
  • Neoplasms, Experimental (drug therapy)
  • Pyrazines (chemical synthesis, therapeutic use)
  • Pyrimethamine (analogs & derivatives)
  • Pyrimidines (chemical synthesis, pharmacology)

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