Abstract |
The synthesis, chemical stability and anti- tumor activity of pyrazine diazohydroxide, sodium salt, a compound that has been selected for development to clinical trials, are described. The compound shows a half-life of about 100 minutes at pH 7.4 and is active against a number of experimental tumors.
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Authors | D C Baker, E S Hand, J Plowman, J B Rampal, A Safavy, R D Haugwitz, V L Narayanan |
Journal | Anti-cancer drug design
(Anticancer Drug Des)
Vol. 2
Issue 3
Pg. 297-309
(Dec 1987)
ISSN: 0266-9536 [Print] United States |
PMID | 3449093
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Azides
- Pyrazines
- Pyrimidines
- pyrazine-2-diazohydroxide
- 3-azidopyrimethamine
- Pyrimethamine
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Topics |
- Animals
- Antineoplastic Agents
(chemical synthesis, therapeutic use)
- Azides
(chemical synthesis, pharmacology)
- Drug Evaluation, Preclinical
- Drug Stability
- Female
- Half-Life
- Male
- Mice
- Mice, Inbred Strains
- Neoplasms, Experimental
(drug therapy)
- Pyrazines
(chemical synthesis, therapeutic use)
- Pyrimethamine
(analogs & derivatives)
- Pyrimidines
(chemical synthesis, pharmacology)
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