Dactimicin, a new, less toxic aminoglycoside antibiotic active against resistant bacteria.

Abstract	Dactimicin is a new member of the pseudodisaccharide group of antibiotics. It possesses an unusual N-formimidoyl group which differentiates it from astromicin. Dactimicin is active against wide variety of bacteria, including resistant strains with aminoglycoside-modifying enzymes. However, AAC(3)-I enzyme slowly acetylates dactimicin. Animal toxicity studies show that the ototoxicity and nephrotoxicity of dactimicin are lower than those of amikacin and gentamicin. No notable abnormal findings have been found in pharmacological and toxicological studies.
Authors	S Omoto, T Yoshida, M Kurebe, S Inouye
Journal	Drugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 13 Issue 12 Pg. 719-25 ( 1987) ISSN: 0378-6501 [Print] Switzerland
PMID	3447874 (Publication Type: Comparative Study, Journal Article)
Chemical References	Aminoglycosides Anti-Bacterial Agents dactimicin fortimicin A Amikacin
Topics	Amikacin (pharmacology) Aminoglycosides Animals Anti-Bacterial Agents (pharmacology, toxicity) Bacteria (drug effects, metabolism) Drug Resistance, Microbial Female Guinea Pigs Hearing Disorders (chemically induced) Kidney Diseases (chemically induced) Male Mice Microbial Sensitivity Tests Rats

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