Antineoplastic activity of azacarbazoles. II. Effect of alpha-carboline and its derivatives on transplantable animal neoplasms.

Abstract

The antineoplastic properties of alpha-carboline, alpha-carboline hydrochloride, alpha-carboline N-1 methyl iodide and c-6 substituted fluoro-, chloro, nitro- and phenyl-alpha-carboline were studied. None of the compounds proved to be active when tested against i.p. transplanted B16 melanoma or i.m. implanted Lewis lung carcinoma. In addition, alpha-carboline was assessed against i.p. inoculated plasmacytoma MP26 and colon carcinoma 26, and solid tumors of mammary carcinoma 16/C and Walker carcinosarcoma 256. Under conditions tested these neoplasms did not respond to alpha-carboline.

• Authors: L Fiszer-Maliszewska, M Mordarski
• Journal: Archivum immunologiae et therapiae experimentalis (Arch Immunol Ther Exp (Warsz)) Vol. 35 Issue 2 Pg. 221-4 ( 1987) ISSN: 0004-069X [Print] Switzerland
• PMID: 3447536 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Carbolines
• alpha-carboline

Topics

• Animals
• Antineoplastic Agents
• Carbolines (pharmacology)
• Drug Screening Assays, Antitumor
• Lung Neoplasms (drug therapy)
• Melanoma, Experimental (drug therapy)
• Mice
• Mice, Inbred Strains
• Neoplasm Transplantation
• Neoplasms, Experimental (drug therapy)
• Transplantation, Isogeneic