Contribution of Interleukin-12A Genotypes to Breast Cancer Risk.

Abstract

BACKGROUND/AIM:

Breast cancer incidence is highest among women worldwide, and practical markers for personalized therapeutic strategies are few. Interleukin-12 (IL-12) is a cytokine that is reported to be significantly lower in healthy controls than breast cancer cases, however, its genotypic contribution to carcinogenesis has never been revealed in breast cancer. We examined whether IL-12A rs568408 and rs2243115 genotypes contribute to elevated breast cancer risk and summarized related literature among other cancers.

MATERIALS AND METHODS:

IL-12A genotypic profiles were determined among 1,232 breast cancer cases and 1,232 healthy controls via polymerase chain reaction-restriction fragment length polymorphism methodology.

RESULTS:

The variant genotypes of IL-12A rs568408 and rs2243115 were not found to be significantly associated with elevated breast cancer risk (both p>0.05).

CONCLUSION:

IL-12A rs568408 and rs2243115 genotypes may not serve as good predictors of breast cancer risk.

• Authors: Yun-Chi Wang, Zhi-Hong Wang, Te-Chun Shen, Wen-Shin Chang, Si-Zein Huang, Chien-Chih Yu, Jaw-Chyun Chen, Yu-Chen Hsiau, Jai-Sing Yang, Chia-Wen Tsai, DA-Tian Bau
• Journal: Anticancer research (Anticancer Res) Vol. 41 Issue 9 Pg. 4387-4393 (Sep 2021) ISSN: 1791-7530 [Electronic] Greece
• PMID: 34475058 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• IL12A protein, human
• Interleukin-12 Subunit p35

Topics

• Adult
• Breast Neoplasms (genetics)
• Case-Control Studies
• Female
• Genetic Association Studies (methods)
• Genetic Predisposition to Disease
• Humans
• Interleukin-12 Subunit p35 (genetics)
• Middle Aged
• Polymorphism, Restriction Fragment Length
• Polymorphism, Single Nucleotide