Abstract |
Effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl] morpholine hydrochloride, YM-08054] on cerebral ischemia were investigated in animals. Indeloxazine prolonged the gasping duration dose-dependently in decapitated mice. Bilateral occlusion of the carotid artery for 5 min shortened the latency of step-through in passive avoidance task 4 days following ischemia in mongolian gerbils. The i.p. administration of indeloxazine was started just after the surgical operation and repeated twice a day for 4 days. Indeloxazine (2 mg/kg) significantly prolonged the latency of step-through in this amnesic model, indicating a reversal effect on the ischemia-induced amnesia. In biochemical studies, decreases in brain ATP and total adenine nucleotide levels were inhibited by indeloxazine (2 mg/kg i.p., once a day for 7 days) in four-vessel occluded rats. These findings indicate that indeloxazine possesses protective effects on cerebral ischemia presumably due, in part, to improvement of the cerebral energy metabolism.
|
Authors | M Yamamoto, M Shimizu, N Sakamoto, H Ohtomo, K Kogure |
Journal | Archives internationales de pharmacodynamie et de therapie
(Arch Int Pharmacodyn Ther)
Vol. 290
Issue 1
Pg. 16-24
(Nov 1987)
ISSN: 0003-9780 [Print] Belgium |
PMID | 3446040
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Animals
- Avoidance Learning
(drug effects)
- Brain
(drug effects, metabolism)
- Brain Ischemia
(drug therapy, metabolism)
- Dose-Response Relationship, Drug
- Energy Metabolism
(drug effects)
- Female
- Gerbillinae
- Male
- Mice
- Mice, Inbred ICR
- Morpholines
(pharmacology)
- Rats
- Rats, Inbred Strains
|