Protective effects of indeloxazine hydrochloride on cerebral ischemia in animals.

Abstract

Effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride, YM-08054] on cerebral ischemia were investigated in animals. Indeloxazine prolonged the gasping duration dose-dependently in decapitated mice. Bilateral occlusion of the carotid artery for 5 min shortened the latency of step-through in passive avoidance task 4 days following ischemia in mongolian gerbils. The i.p. administration of indeloxazine was started just after the surgical operation and repeated twice a day for 4 days. Indeloxazine (2 mg/kg) significantly prolonged the latency of step-through in this amnesic model, indicating a reversal effect on the ischemia-induced amnesia. In biochemical studies, decreases in brain ATP and total adenine nucleotide levels were inhibited by indeloxazine (2 mg/kg i.p., once a day for 7 days) in four-vessel occluded rats. These findings indicate that indeloxazine possesses protective effects on cerebral ischemia presumably due, in part, to improvement of the cerebral energy metabolism.

• Authors: M Yamamoto, M Shimizu, N Sakamoto, H Ohtomo, K Kogure
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 290 Issue 1 Pg. 16-24 (Nov 1987) ISSN: 0003-9780 [Print] Belgium
• PMID: 3446040 (Publication Type: Journal Article)

Chemical References

• Morpholines
• indeloxazine

Topics

• Animals
• Avoidance Learning (drug effects)
• Brain (drug effects, metabolism)
• Brain Ischemia (drug therapy, metabolism)
• Dose-Response Relationship, Drug
• Energy Metabolism (drug effects)
• Female
• Gerbillinae
• Male
• Mice
• Mice, Inbred ICR
• Morpholines (pharmacology)
• Rats
• Rats, Inbred Strains