Abstract |
Tumor cells grown in the presence of 1-O-alkyl-2-O-methylglycero-3-phosphocholine ( AMG-PC) accumulated this ether lipid in their membranes. Depending on the cell type and the dose of the compound, up to 17% of the total phospholipids of the purified plasma membranes consisted of authentic AMG-PC. Extensive incorporation of the agent resulted in a decrease in plasma membrane fluidity and inhibition of tumor cell invasiveness in embryonic chick heart fragments. The extent of AMG-PC incorporation and fluidity change was not strictly correlated with the degree to which tumor cell invasion was inhibited.
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Authors | W J van Blitterswijk, H Hilkmann, G A Storme |
Journal | Lipids
(Lipids)
Vol. 22
Issue 11
Pg. 820-3
(Nov 1987)
ISSN: 0024-4201 [Print] United States |
PMID | 3444372
(Publication Type: Journal Article)
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Chemical References |
- Glyceryl Ethers
- Phospholipid Ethers
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Topics |
- Animals
- Cell Line
- Glyceryl Ethers
(pharmacokinetics, pharmacology)
- Membrane Fluidity
(drug effects)
- Phospholipid Ethers
(pharmacokinetics, pharmacology)
- Rats
- Subcellular Fractions
(drug effects)
- Tumor Cells, Cultured
(drug effects)
- Tumor Stem Cell Assay
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