Prevalence, Temporal Change, and Determinants of Anxiety and Depression in Hospitalized Patients With Heart Failure.

Abstract

BACKGROUND:

Anxiety and depression may be under-recognized in patients with heart failure (HF). We therefore investigated the prevalence and temporal change of these symptoms in hospitalized patients with HF.

METHODS AND RESULTS:

We prospectively evaluated consecutive hospitalized patients with HF using the Hospital Anxiety and Depression Scale (HADS) on admission and at discharge. The HADS-A (anxiety) and HADS-D (depression) scores were categorized as follows; 0-7, no symptoms; 8-10, mild; and 11-21, significant anxiety or depression. Symptom worsening was defined as the HADS category at discharge being poorer than that on admission. Of 224 patients (mean age 77.5 years), 35 (16%) and 62 (28%) had significant symptoms of anxiety and depression, respectively. During hospitalization, the HADS-A significantly decreased (on admission; median 6 [interquartile range (IQR) 3-9] vs at discharge; median 4 [IQR 2-7], P < .01), whereas the HADS-D did not improve (on admission; median 8 [IQR 5-11] vs at discharge; median 8 [IQR 4-11], P =.82). Anxiety and depression worsened during hospitalization in 19 (10%) and 40 (21%) patients, respectively. Advanced age, higher natriuretic peptide levels, and acute-on-chronic HF were associated with worsening anxiety, and longer hospitalization length was associated with worsening depression.

CONCLUSIONS:

Anxiety and depression were common and depression persisted during HF hospitalization.

• Authors: Yasuhiro Hamatani, Moritake Iguchi, Yurika Ikeyama, Atsuko Kunugida, Megumi Ogawa, Natsushige Yasuda, Kana Fujimoto, Hidenori Ichihara, Misaki Sakai, Tae Kinoshita, Yasuyo Nakashima, Masaharu Akao
• Journal: Journal of cardiac failure (J Card Fail) Vol. 28 Issue 2 Pg. 181-190 (02 2022) ISSN: 1532-8414 [Electronic] United States
• PMID: 34419596 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Topics

• Aged
• Anxiety (diagnosis, epidemiology)
• Depression (diagnosis, epidemiology, etiology)
• Heart Failure (diagnosis, epidemiology)
• Hospitalization
• Humans
• Prevalence