Influence of N,N'-(1,11-undecandiyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide) (BAY 02752) on gallstone formation and regression in hamsters.

Abstract

A new hypolipidemic drug (BAY 02752) when added to a lithogenic hamster diet at dosages of 1000 and 500 mg per kg of diet significantly (p less than 0.005) inhibited gallstone formation. When BAY 02752 was fed to hamsters with pre-established gallstones, it inhibited progression (p=0.052) of the stones and appeared to promote dissolution.

• Authors: D Kritchevsky, D M Klurfeld
• Journal: Pharmacological research communications (Pharmacol Res Commun) Vol. 19 Issue 10 Pg. 679-84 (Oct 1987) ISSN: 0031-6989 [Print] United States
• PMID: 3441483 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hypolipidemic Agents
• Indoles
• Bay 02752

Topics

• Animals
• Cholelithiasis (drug therapy, prevention & control)
• Cricetinae
• Diet
• Hypolipidemic Agents (therapeutic use)
• Indoles (therapeutic use)
• Male
• Mesocricetus