Abstract | BACKGROUND: It had not been reported that myocardial scar shown on gated myocardial perfusion SPECT ( GMPS) might reduce after cardiac resynchronization therapy (CRT). In this study, we aim to investigate the clinical impact and characteristic of scar reduction (SR) after CRT. METHODS AND RESULTS: Sixty-one heart failure patients following standard indication for CRT received twice GMPS as pre- and post-CRT evaluations. The patients with an absolute reduction of scar ≥ 10% after CRT were classified as the SR group while the rest were classified as the non-SR group. The SR group (N = 22, 36%) showed more improvement on LV function (∆LVEF: 18.1 ± 12.4 vs 9.4 ± 9.9 %, P = 0.007, ∆ESV: - 91.6 ± 52.6 vs - 38.1 ± 46.5 mL, P < 0.001) and dyssynchrony (ΔPSD: - 26.19 ± 18.42 vs - 5.8 ± 23.0°, P < 0.001, Δ BW: - 128.7 ± 82.8 vs - 25.2 ± 109.0°, P < 0.001) than non-SR group (N = 39, 64%). Multivariate logistic regression analysis showed baseline QRSd (95% CI 1.019-1.100, P = 0.006) and pre-CRT Reduced Wall Thickening (RWT) (95% CI 1.016-1.173, P = 0.028) were independent predictors for the development of SR. CONCLUSION: More than one third of patients showed SR after CRT who had more post-CRT improvement on LV function and dyssynchrony than those without SR. Wider QRSd and higher RWT before CRT were related to the development of SR after CRT.
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Authors | Chi-Yen Wang, Guang-Uei Hung, Hsu-Chung Lo, Shih-Chuan Tsai, Zhuo He, Xinwei Zhang, Kuo-Feng Chiang, Jiangang Zou, Weihua Zhou, Jin-Long Huang, Shih-Ann Chen |
Journal | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
(J Nucl Cardiol)
Vol. 29
Issue 5
Pg. 2571-2579
(Oct 2022)
ISSN: 1532-6551 [Electronic] United States |
PMID | 34414552
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. American Society of Nuclear Cardiology. |
Chemical References |
- Thionucleotides
- guanosine 5'-monophosphorothioate
- Guanosine Monophosphate
|
Topics |
- Cardiac Resynchronization Therapy
(methods)
- Cicatrix
(diagnostic imaging)
- Guanosine Monophosphate
- Heart Failure
(diagnostic imaging, therapy)
- Humans
- Myocardial Perfusion Imaging
(methods)
- Perfusion
- Thionucleotides
- Tomography, Emission-Computed, Single-Photon
(methods)
- Treatment Outcome
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