Abstract |
Twenty male combinative cocaine free-base/ phencyclidine (space-base) abusers were studied for forty-five days, in a double-blind design. Treatment with desipramine was significantly more effective than placebo in alleviating abstinence symptoms. This study tends to support the catecholamine-depletion hypothesis of cocaine and phencyclidine withdrawal.
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Authors | A J Giannini, R H Loiselle, M C Giannini |
Journal | Journal of toxicology. Clinical toxicology
(J Toxicol Clin Toxicol)
Vol. 25
Issue 6
Pg. 493-500
( 1987)
ISSN: 0731-3810 [Print] United States |
PMID | 3441016
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Cocaine
- Phencyclidine
- Desipramine
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Topics |
- Adult
- Cocaine
(adverse effects)
- Desipramine
(therapeutic use)
- Double-Blind Method
- Humans
- Male
- Phencyclidine
(adverse effects)
- Psychotherapy, Brief
- Substance Withdrawal Syndrome
(drug therapy)
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