Randomized controlled trial of Syn-Ergel and an active placebo in the treatment of heartburn of pregnancy.

Abstract

A randomized controlled trial was performed to study the efficacy of Syn-Ergel with an active placebo in the treatment of heartburn of pregnancy in ninety-two patients completing 7 days of therapy. Syn-Ergel was significantly better (p less than 0.001) in all groups of pre-treatment pain severity in relieving the symptoms, and had a longer duration of action, than the active placebo. Complete relief of pain was achieved in 79.5% of Syn-Ergel treatments with a further 10% of treatments resulting in marked easing of discomfort at 1 hour following administration. The corresponding figures for the 'active placebo' were 56% and 20%. The combination of an antacid and a protective mucosal coating agent would appear to be a useful approach in the treatment of heartburn of pregnacy.

• Authors: R W Shaw
• Journal: The Journal of international medical research (J Int Med Res) Vol. 6 Issue 2 Pg. 147-51 ( 1978) ISSN: 0300-0605 [Print] England
• PMID: 344087 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antacids
• Drug Combinations
• Placebos
• Syn-ergel
• Pectins
• Agar
• Aluminum

Topics

• Agar (therapeutic use)
• Aluminum (therapeutic use)
• Antacids (therapeutic use)
• Clinical Trials as Topic
• Drug Combinations
• Drug Evaluation
• Female
• Heartburn (drug therapy)
• Humans
• Pectins (therapeutic use)
• Placebos
• Pregnancy
• Pregnancy Complications (drug therapy)
• Pregnancy Trimester, Third