Adsorption of bile acids by sucralfate, antacids, and cholestyramine in vitro.

Abstract

Sucralfate, one of the newer drugs shown to be effective in the treatment of peptic ulcer and esophagitis; cholestyramine, a known bile acid binder; and commercial antacid preparations of pure aluminum hydroxide, pure magnesium hydroxide, and a combination of aluminum hydroxide, magnesium hydroxide, and magnesium carbonate were tested in vitro for bile acid-binding capacity. Cholestyramine was found to be the most effective bile acid binder, with more than 90% of bile acids adsorbed at all of the pH values studied. Sucralfate proved efficacious at pH 4, 6, and 8, adsorbing about 50% of the bile acids, but its binding capacity decreased at pH 2. Pure aluminum hydroxide was the most effective of the various antacid preparations; it adsorbed about 90% of bile acids at pH 2, although this percentage was significantly reduced at pH 6 and 8. Sucralfate was significantly more effective as a bile acid absorbent at pH 4 than either the magnesium hydroxide or aluminum-magnesium hydroxide plus magnesium carbonate antacids, as effective as the aluminum hydroxide antacid, and significantly less effective than cholestyramine.

• Authors: M Ståhlberg, P Jalovaara, S Laitinen, R Mokka, R Hentilä, P Järvensivu, M Kairaluoma
• Journal: Clinical therapeutics (Clin Ther) Vol. 9 Issue 6 Pg. 615-21 ( 1987) ISSN: 0149-2918 [Print] United States
• PMID: 3440273 (Publication Type: Journal Article)

Chemical References

• Antacids
• Bile Acids and Salts
• Cholestyramine Resin
• Sucralfate

Topics

• Adsorption
• Antacids
• Bile Acids and Salts (metabolism)
• Cholestyramine Resin
• Humans
• Hydrogen-Ion Concentration
• Sucralfate