Success of Cyclosporin and Tofacitinib Combination Therapy in a Patient With Severe Steroid-refractory Ulcerative Colitis.

Abstract

At present, the conventional therapies for acute severe ulcerative colitis (ASUC) mainly include corticosteroids, cyclosporin, and biological agents. However, the treatment of patients with severe steroid-refractory ulcerative colitis remains a serious challenge to clinicians. This study reports a case of steroid-refractory ASUC treated with cyclosporin combined with tofacitinib after treatment failure with infliximab.

• Authors: Qinglu Yang, Liang Chen, Lijin Feng, Changqin Liu, Leilei Fang, Zhanju Liu, Xiaomin Sun
• Journal: Inflammatory bowel diseases (Inflamm Bowel Dis) Vol. 27 Issue 12 Pg. e157-e158 (11 15 2021) ISSN: 1536-4844 [Electronic] England
• PMID: 34398196 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Piperidines
• Pyrimidines
• Steroids
• Cyclosporine
• tofacitinib

Topics

• Colitis, Ulcerative (drug therapy)
• Cyclosporine (therapeutic use)
• Humans
• Piperidines (therapeutic use)
• Pyrimidines (therapeutic use)
• Steroids