Abstract | BACKGROUND: METHODS: We retrospectively reviewed 66 intracranial HPC patients treated between 1999 and 2019 including 29 with surgery followed by radiotherapy (11 with intensity-modulated radiotherapy (IMRT) and 18 with stereotactic radiosurgery (SRS)) and 37 with surgery alone. Chi-square test was used to compare the clinical characteristic between the groups. The Kaplan-Meier method was used to analyze overall survival (OS) and recurrence-free survival (RFS). Multivariate Cox proportional hazards models were used to examine prognostic factors of survival. We also underwent a matched-pair analysis by using the propensity score method. RESULTS: The crude local control rates were 58.6% in the surgery plus post-operative radiotherapy group (PORT) and 67.6% in the surgery alone group (p = 0.453). In the subgroup analysis of the PORT patients, local controls were 72.7% in the IMRT group and 50% in the SRS group (p = 0.228). The median OS in the PORT and surgery groups were 122 months and 98 months, respectively (p = 0.169). The median RFS was 96 months in the PORT group and 72 months in the surgery alone group (p = 0.714). Regarding radiotherapy technique, the median OS and RFS of the SRS group were not significantly different from those in the IMRT group (p = 0.256, 0.960). The median RFS were 112 and 72 months for pathology grade II and III patients, respectively (p = 0.001). Propensity score matching did not change the observed results. CONCLUSION: In this retrospective analysis, PORT did not improve the local control rates nor the survivals. The local control rates after IMRT and SRS were similar even though the IMRT technique had a much higher biological dose compared with the SRS technique.
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Authors | Jianbiao Xiao, Lanwei Xu, Yi Ding, Wei Wang, Fen Chen, Yangshu Zhou, Fengjiao Zhang, Qiyuan Zhou, Xuehui Wu, Junpeng Li, Li Liang, Yee-Min Jen |
Journal | BMC cancer
(BMC Cancer)
Vol. 21
Issue 1
Pg. 915
(Aug 12 2021)
ISSN: 1471-2407 [Electronic] England |
PMID | 34384377
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s). |
Topics |
- Adult
- Aged
- Brain Neoplasms
(diagnosis, mortality, radiotherapy)
- Combined Modality Therapy
- Female
- Hemangiopericytoma
(diagnosis, mortality, radiotherapy)
- Humans
- Kaplan-Meier Estimate
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neoplasm Grading
- Postoperative Care
- Proportional Hazards Models
- Radiosurgery
- Radiotherapy, Intensity-Modulated
- Recurrence
- Retrospective Studies
- Treatment Outcome
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