New derivatives of amino alcohols with antiarrhythmic activity.

Abstract

Nine new N-acyl derivatives of 2-amino-1-alcohols and 1-amino-2-alcohols with a potential arrhythmic activity have been obtained. In the preliminary screening 2-[N-(7-theophyllineacetyl)-amino]-2-methyl-1-propanol, 5, was more active in the chloroform-induced arrhythmia than quinidine. Unlike to propranolol and quinidine, compound 5 in doses of 5-30 mg/kg, iv, did not prevent distortions of the cardiac rhythm evoked by adrenaline and strophanthine. When administered at the peak of arrhythmia, it did not abolish disturbances of the cardiac rhythm. Compound 5 had a low toxicity (LD50 = 3000 mg/kg, ip), did not change the control ECG curve, showed no cardiodepressive activity, and had weaker local anesthetic properties than lignocaine.

• Authors: M Eckstein, M Cegła, J Krupińska, B Cebo, M Michna
• Journal: Polish journal of pharmacology and pharmacy (Pol J Pharmacol Pharm) 1987 May-Jun Vol. 39 Issue 3 Pg. 317-22 ISSN: 0301-0244 [Print] Poland
• PMID: 3438214 (Publication Type: Journal Article)

Chemical References

• Amino Alcohols
• Anti-Arrhythmia Agents

Topics

• Amino Alcohols (pharmacology)
• Animals
• Anti-Arrhythmia Agents
• Drug Evaluation, Preclinical
• Guinea Pigs
• In Vitro Techniques
• Male
• Mice
• Rats
• Rats, Inbred Strains