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A dandelion polysaccharide and its selenium nanoparticles: Structure features and evaluation of anti-tumor activity in zebrafish models.

Abstract
In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable spherical nanoparticle (Tw-TMP-SeNP, 50 nm) was fabricated. Physico-chemical analysis revealed that TMP50-2 and Tween 80 were tightly wrapped on the surface of SeNPs by forming CO⋯Se bonds or through hydrogen bonding interaction (OH⋯Se). In vitro anti-tumor assay showed that Tw-TMP-SeNP treatment could significantly inhibit the proliferation of cancer cells (HepG2, A549, and HeLa) in a dose-dependent manner, while HepG2 cells were more susceptible to Tw-TMP-SeNP with an IC50 value of 46.8 μg/mL. The apoptosis induction of HepG2 cells by Tw-TMP-SeNP was evidenced by increasing the proportion of apoptotic cells ranging from 12.5% to 27.4%. Furthermore, in vivo zebrafish model confirmed the anti-tumor activity of Tw-TMP-SeNP by inhibiting the proliferation and migration of tumor cells as well as the angiogenesis of zebrafish embryos.
AuthorsShaojie Zhang, Ziteng Song, Lijuan Shi, Linan Zhou, Jie Zhang, Jianlin Cui, Yuhao Li, Da-Qing Jin, Yasushi Ohizumi, Jing Xu, Yuanqiang Guo
JournalCarbohydrate polymers (Carbohydr Polym) Vol. 270 Pg. 118365 (Oct 15 2021) ISSN: 1879-1344 [Electronic] England
PMID34364610 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Fructans
  • Polysaccharides
  • Selenium
Topics
  • A549 Cells
  • Animals
  • Antineoplastic Agents (pharmacology)
  • Apoptosis (drug effects)
  • Cell Proliferation (drug effects)
  • Fructans (chemistry, pharmacology)
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Hydrogen Bonding
  • Nanoparticles (chemistry)
  • Neoplasms (drug therapy, metabolism, pathology)
  • Polysaccharides (chemistry, pharmacology)
  • Selenium (chemistry, pharmacology)
  • Taraxacum (chemistry)
  • Zebrafish

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