Abstract |
A prospective trial was designed to assess the effectiveness of three different concentrations of bupivacaine ( Marcain) for use in obstetric epidural analgesia. The purpose of the study was to see if reduction of the concentration of bupivacaine to 0.125% would reduce the total dose of the drug given without reducing the efficiency of the epidural block. The concentrations studies were 0.125%, 0.25% and 0.375%. The trial was limited to fit primiparous patients at term with singleton pregnancies and vertex presentation. Patients with intercurrent medical disease or with toxaemia were excluded. A total of ninety-three patients were studied, and once admitted to the trial they were randomly allocated to one of the three concentrations. In general the results of the trial show that 0.125% bupivacaine had a significantly higher failure rate than either of the other two concentrations, but in those cases where 0.125% was effective and achieved total pain relief there was a significant reduction in the amount of the drug used.
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Authors | S F Stainthorp, E G Bradshaw, P D Challen, M A Tobias |
Journal | Anaesthesia
(Anaesthesia)
Vol. 33
Issue 1
Pg. 3-9
(Jan 1978)
ISSN: 0003-2409 [Print] England |
PMID | 343630
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Anesthesia, Epidural
- Anesthesia, Obstetrical
- Bupivacaine
(administration & dosage)
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Humans
- Pregnancy
- Prospective Studies
- Time Factors
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