Abstract |
The purpose of this study was to evaluate VAP combination chemotherapy in advanced breast cancer: prednimustine 80 mg/m2 p.o. days 1-5, adriamycin 40 mg/m2 and vincristine 1.4 mg/m2 1st day in cycles of 3 weeks. Twenty-one women entered the study and 19 were evaluable. The mean age was 54.5 years (25-69) with an average performance status of 60 according to Karnofsky. Hormonal receptors were unknown in 10, positive in 6 and negative in 3. The dominant site of disease was soft tissues in 11, bones in 1, liver in 3 and lung in 4. Fourteen patients had as prior treatment cyclophosphamide, methotrexate and 5-fluorouracil (CMF), two had tamoxifen and three none. Ten patients (52.6%) had a partial response with a mean survival of 7.8+ months, 5 patients (26.3%) had stable disease with a mean survival 6.6+ months and 4 patients (21.1%) had progressive disease with a mean survival of 3 months. Regarding toxicity all patients had alopecia, most of the patients had nausea grade I, whereas 5 patients developed mild leukopenia. We conclude that VAP is an effective, well tolerated chemotherapy combination in patients with advanced breast cancer which deserves further clinical trials.
|
Authors | P A Kosmidis, G Fountzilas, A Athanassiou, A Karabelis, N Mylonakis, N Tsavaris, N Karvounis, C Bacojiannis |
Journal | Chemioterapia : international journal of the Mediterranean Society of Chemotherapy
(Chemioterapia)
Vol. 6
Issue 6
Pg. 393-5
(Dec 1987)
ISSN: 0392-906X [Print] Italy |
PMID | 3435921
(Publication Type: Journal Article)
|
Chemical References |
- Vincristine
- Doxorubicin
- Prednimustine
|
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Breast Neoplasms
(drug therapy)
- Doxorubicin
(administration & dosage)
- Drug Evaluation
- Female
- Humans
- Middle Aged
- Prednimustine
(administration & dosage)
- Vincristine
(administration & dosage)
|