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Neuropeptide-dopamine interactions. I. Dopaminergic mechanisms in cyclo(His-Pro)-mediated hypothermia in rats.

Abstract
Administration of cyclo(His-Pro) to rats produces a dose-dependent hypothermia that is attenuated by dopaminergic antagonists. Chronic treatment with cyclo(His-Pro) potentiates hypothermia induced by apomorphine. These results suggest that cyclo(His-Pro) acts via a dopaminergic mechanism to modulate body temperature.
AuthorsC Prasad
JournalBrain research (Brain Res) Vol. 437 Issue 2 Pg. 345-8 (Dec 29 1987) ISSN: 0006-8993 [Print] Netherlands
PMID3435841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Peptides, Cyclic
  • Piperazines
  • histidyl-proline diketopiperazine
  • Dopamine
Topics
  • Animals
  • Body Temperature Regulation (drug effects)
  • Dopamine (physiology)
  • Dose-Response Relationship, Drug
  • Male
  • Peptides, Cyclic (pharmacology)
  • Piperazines (pharmacology)
  • Rats
  • Rats, Inbred Strains
  • Reference Values

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