Abstract | CONTEXT.—: The process for identifying patients with monoclonal gammopathies is complex. Initial detection of a monoclonal immunoglobulin protein (M protein) in the serum or urine often requires compilation of analytical data from several areas of the laboratory. The detection of M proteins depends on adequacy of the sample provided, available clinical information, and the laboratory tests used. OBJECTIVE.—: To develop an evidence-based guideline for the initial laboratory detection of M proteins. DESIGN.—: To develop evidence-based recommendations, the College of American Pathologists convened a panel of experts in the diagnosis and treatment of monoclonal gammopathies and the laboratory procedures used for the initial detection of M proteins. The panel conducted a systematic literature review to address key questions. Using the Grading of Recommendations Assessment, Development, and Evaluation approach, recommendations were created based on the available evidence, strength of that evidence, and key judgements as defined in the Grading of Recommendations Assessment, Development, and Evaluation Evidence to Decision framework. RESULTS.—: Nine guideline statements were established to optimize sample selection and testing for the initial detection and quantitative measurement of M proteins used to diagnose monoclonal gammopathies. CONCLUSIONS.—:
|
Authors | David F Keren, Gregary Bocsi, Brooke L Billman, Joan Etzell, James D Faix, Shaji Kumar, Brea Lipe, Christopher McCudden, Roberta Montgomery, David L Murray, Alex J Rai, Teresita Cuyegkeng Redondo, Lesley Souter, Christina B Ventura, Mohammad Qasim Ansari |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 146
Issue 5
Pg. 575-590
(05 01 2022)
ISSN: 1543-2165 [Electronic] United States |
PMID | 34347866
(Publication Type: Journal Article, Practice Guideline)
|
Topics |
- Humans
- Laboratories
- Paraproteinemias
(diagnosis)
- Systematic Reviews as Topic
|