Abstract |
Fifteen (12.7%) among 118 cases of the West syndrome were effectively treated by high-dose pyridoxal phosphate (PAL-P). 1) Clinical seizures were completely suppressed in 12 cases with PAL-P alone, and in 3 cases by an addition of PAL-P to the previously poorly-effective regimen. At the follow-up, 12 cases have continued to be free from seizures, while two cases relapsed into the Lennox-Gastaut syndrome, and one died. 2) Electroencephalographically hypsarhythmia disappeared by PAL-P in all 15 effective cases. 3) Effective daily dose of PAL-P was 30 to 400 mg. 4) Notably, PAL-P was effective even in the cases with obvious organic brain pathology, such as tuberous sclerosis, porencephaly, holoprosencephaly, postmeningitis, besides 5 idiopathic cases. 5) Efficacy of PAL-P was significantly higher in idiopathic cases than symptomatic cases; 35.7% vs 9.6%. 6) Response to PAL-P was not predictable by any laboratory data nor clinical features. 7) Prognosis of PAL-P responsive cases was favorable; as many as 6 cases developed normally among 14 cases followed-up. Treatment with a high-dose PAL-P should be tried in all cases of the West syndrome at first.
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Authors | Y Ohtsuka, M Matsuda, T Ogino, K Kobayashi, S Ohtahara |
Journal | Brain & development
(Brain Dev)
Vol. 9
Issue 4
Pg. 418-21
( 1987)
ISSN: 0387-7604 [Print] Netherlands |
PMID | 3434717
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Adolescent
- Child
- Child, Preschool
- Electroencephalography
- Follow-Up Studies
- Humans
- Infant
- Injections, Intramuscular
- Pyridoxal Phosphate
(administration & dosage, therapeutic use)
- Spasms, Infantile
(drug therapy, physiopathology)
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