[Protective action of remantadine in experimental influenzal-staphylococcal infection].

The effect of remantadine on the course of influenzal-staphylococcal infection was studied in white mice. When the drug was injected to the mice infected with remantadine-sensitive strain of influenza A virus and Staphylococcus the lethality decreased from 93.3% to 26.7%, the survival time increased from 3.8 to 10.1 days, the incidence of pneumonia decreased from 85.7% to 48.7%, the average intensity of pneumonia decreased from 66.4% to 9.9%, and virus titres in the lungs decreased by 3.5-4.0 lg EID50 (p less than 0.05). In the groups of mice infected with remantadine-resistant strain of influenza virus and Staphylococcus remantadine showed no significant effect on these parameters: the lethality decreased by 6.7% only, the average survival time increased only by 0.33 days, the incidence of pneumonia decreased by 9%, its intensity by 19.2%; influenza virus titres in the lung tissue did not change significantly.
AuthorsM L Medvedev, A M Koroliuk
JournalVoprosy virusologii (Vopr Virusol) 1987 Sep-Oct Vol. 32 Issue 5 Pg. 538-40 ISSN: 0507-4088 [Print] USSR
Vernacular TitleZashchitnoe deĭstvie remantadina pri éksperimental'noĭ grippozno-stafilokokkovoĭ infektsii.
PMID3433711 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Rimantadine
  • Adamantane
  • Adamantane (analogs & derivatives)
  • Animals
  • Drug Evaluation, Preclinical
  • Drug Resistance, Microbial
  • Influenza A virus (drug effects, physiology)
  • Mice
  • Orthomyxoviridae Infections (drug therapy, mortality)
  • Rimantadine (therapeutic use)
  • Staphylococcal Infections (drug therapy, mortality)
  • Time Factors
  • Virus Replication (drug effects)

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