Treatment of intestinal amoebiasis and vaginal trichomoniasis with panidazole and its comparison with metronidazole.

Abstract

A dose range study in 18 patients suffering from intestinal amoebiasis and treated with doses of panidazole between 1.0 and 2.0 g per day for six days revealed that the best therapeutic results were obtained with the higher dose. This dose was then compared with metronidazole, at the same dose, in a clinical trial in 100 patients with intestinal amoebiasis. Cure rates were 68% and 80% for the two drugs respectively. In 100 cases of vaginal trichomoniasis treated with panidazole at the dose of 1.0 g per day for seven days in half of the patients and for 10 days in the other half, we obtained 50% and 60% cure rates. The results of our studies with both amoebiasis and trichomoniasis were not superior to those obtained with metronidazole and other nitroimidazole derivatives. Side effects were found in 74% of the patients treated for amoebiasis and in 46% of the cases treated for trichomoniasis. No toxic effects were revealed by haematological, biochemical and renal function tests nor by cardiovascular studies.

• Authors: D Botero, A Perez
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene (Trans R Soc Trop Med Hyg) Vol. 71 Issue 6 Pg. 508-11 ( 1977) ISSN: 0035-9203 [Print] England
• PMID: 343312 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Amebicides
• Nitroimidazoles
• Pyridines
• panidazole
• Metronidazole

Topics

• Adult
• Amebicides (therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Dysentery, Amebic (drug therapy)
• Female
• Humans
• Male
• Metronidazole (adverse effects, therapeutic use)
• Nitroimidazoles (administration & dosage, adverse effects, therapeutic use)
• Pyridines (therapeutic use)
• Trichomonas Vaginitis (drug therapy)