Successful Treatment with High-Dose Chemotherapy Followed by Autologous Stem-Cell Transplantation in a Patient with Metastatic Germ Cell Tumor.

Abstract

Although testicular germ cell tumors (GCTs) are known to curable disease even in cases with metastatic disease, patients in intermediate or poor-risk group may experience disease progression or refractory to the initial chemotherapy and needed second-line therapy. Long-term disease-free survival was unsatisfactory in relapsed/refractory patients with poor-risk factors and clinical trials for those patients are still insufficient. High-dose chemotherapy (HDCT) with stem-cell rescue may be an effective alternative for conventional chemotherapy-resistant patients who are eligible for transplantation. Herein, we present successful treatment experience with HDCT followed by autologous stem-cell transplantation in a severely ill patient with heavily pretreated metastatic GCT.

• Authors: Jung Min Lee, Byung Woog Kang, Man-Hoon Han, Dong Won Baek
• Journal: Case reports in oncology (Case Rep Oncol) 2021 May-Aug Vol. 14 Issue 2 Pg. 998-1003 ISSN: 1662-6575 [Print] Switzerland
• PMID: 34326734 (Publication Type: Case Reports)
• Copyright: Copyright © 2021 by S. Karger AG, Basel.