Is cystectomy an option as conservative surgery for young patients with borderline ovarian tumor? A multi-institutional retrospective study.

Abstract

OBJECTIVE:

To investigate the impact of cystectomy for borderline ovarian tumor (BOT) on tumor recurrence compared with salpingo-oophorectomy using inverse probability of treatment weighting (IPTW).

METHODS:

A central pathologic review and a search of the medical records from 14 collaborating institutions from 1986 to 2017 identified 4708 women with a malignant ovarian neoplasm. Data for young women with Stage I BOT were extracted. To compare recurrence-free survival between the surgery groups, Cox regression analyses and the IPTW-adjusted Kaplan-Meier method were employed.

RESULTS:

During a median follow-up of 62.0 (1.2-270.4) months, 10 of the 285 patients identified (3.5%) developed recurrence. In multivariate analysis, the practice of cystectomy was not a significant prognostic indicator of recurrence-free survival (hazard ratio [95% confidence interval] 1.276 [0.150-10.864]; P = 0.823). In the IPTW-adjusted cohort, the 5-year recurrence-free survival rates were 95.8% and 96.0% in patients receiving cystectomy and salpingo-oophorectomy, respectively (P = 0.378).

CONCLUSION:

If patients are selected appropriately, cystectomy in itself may not increase tumor recurrence in young women with early-stage BOT. A large-scale prospective clinical study is necessary to validate this finding.

• Authors: Yoshiki Ikeda, Masato Yoshihara, Nobuhisa Yoshikawa, Satoshi Tamauchi, Akira Yokoi, Kimihiro Nishino, Kaoru Niimi, Hiroaki Kajiyama
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 157 Issue 2 Pg. 437-443 (May 2022) ISSN: 1879-3479 [Electronic] United States
• PMID: 34324200 (Publication Type: Journal Article, Multicenter Study)
• Copyright: © 2021 International Federation of Gynecology and Obstetrics.

Topics

• Cystectomy
• Female
• Humans
• Neoplasm Recurrence, Local (pathology)
• Neoplasm Staging
• Ovarian Neoplasms (pathology)
• Ovariectomy (methods)
• Prospective Studies
• Retrospective Studies