HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Tumor imaging with anti-CEA antibody labeled 19F emulsion.

Abstract
The possibility of using 19F MRI for detection of tumors using a 2-T NMR system was examined in animals. Anticarcino-embryonic antigen (CEA) antibody conjugated with perfluorochemical (perfluorotributylamine, FTBA) was administered to nude mouse inoculated with LOVO, a CEA-producing human cancer cell line. Tumor imaging based on the 19F NMR was examined after excision of the tumors from nude mice (ex vivo). The imaging pattern of the tumor coincided with the antibody distribution determined immunohistologically.
AuthorsM Shimizu, T Kobayashi, H Morimoto, N Matsuura, T Shimano, N Nomura, S Itoh, M Yamazaki, N Iriguchi, T Yamamoto
JournalMagnetic resonance in medicine (Magn Reson Med) Vol. 5 Issue 3 Pg. 290-5 (Sep 1987) ISSN: 0740-3194 [Print] United States
PMID3431398 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Neoplasm
  • Carcinoembryonic Antigen
  • Fluorine
Topics
  • Animals
  • Antibodies, Neoplasm
  • Carcinoembryonic Antigen (immunology)
  • Fluorine
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Neoplasms, Experimental (diagnosis)
  • Transplantation, Heterologous

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: