Abstract |
The possibility of using 19F MRI for detection of tumors using a 2-T NMR system was examined in animals. Anticarcino-embryonic antigen (CEA) antibody conjugated with perfluorochemical ( perfluorotributylamine, FTBA) was administered to nude mouse inoculated with LOVO, a CEA-producing human cancer cell line. Tumor imaging based on the 19F NMR was examined after excision of the tumors from nude mice (ex vivo). The imaging pattern of the tumor coincided with the antibody distribution determined immunohistologically.
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Authors | M Shimizu, T Kobayashi, H Morimoto, N Matsuura, T Shimano, N Nomura, S Itoh, M Yamazaki, N Iriguchi, T Yamamoto |
Journal | Magnetic resonance in medicine
(Magn Reson Med)
Vol. 5
Issue 3
Pg. 290-5
(Sep 1987)
ISSN: 0740-3194 [Print] United States |
PMID | 3431398
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Neoplasm
- Carcinoembryonic Antigen
- Fluorine
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Topics |
- Animals
- Antibodies, Neoplasm
- Carcinoembryonic Antigen
(immunology)
- Fluorine
- Humans
- Magnetic Resonance Imaging
(methods)
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Neoplasms, Experimental
(diagnosis)
- Transplantation, Heterologous
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