Cefonicid vs. cefoxitin for cesarean section prophylaxis.

Abstract

A randomized, prospective study compared a long-acting, second-generation cephalosporin, cefonicid (Monocid), with a short-acting, second-generation cephalosporin, cefoxitin (Mefoxin), for cesarean section prophylaxis. One hundred thirty-nine patients were enrolled, with 81 receiving a 1-g intravenous dose of cefonicid after cord clamping and 58 receiving a 2-g dose of intravenous cefoxitin after cord clamping and at 6, 12 and 18 hours postpartum. In those patients receiving cefonicid prophylaxis, endometritis incidence was 17.3% (14 of 81). This finding was not statistically significant (P less than .397) when compared to the 12.1% incidence of endometritis (7 of 58) with cefoxitin. In addition, the febrile morbidity incidence for cefonicid prophylaxis was 23.5% (19 of 81) as compared to 15.5% (9 of 58) for cefoxitin (P less than .25). Because the two drugs appear to be equally efficacious, cefonicid may be the better choice because of its markedly lower cost.

• Authors: R A Hartert Jr, G Benrubi, R J Thompson, R C Nuss
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 32 Issue 12 Pg. 907-10 (Dec 1987) ISSN: 0024-7758 [Print] United States
• PMID: 3430499 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Cefamandole
• Cefonicid
• Cefoxitin

Topics

• Adult
• Age Factors
• Cefamandole (analogs & derivatives, therapeutic use)
• Cefonicid
• Cefoxitin (therapeutic use)
• Cesarean Section (adverse effects)
• Endometritis (economics, prevention & control)
• Female
• Humans
• Pregnancy
• Prospective Studies
• Random Allocation
• Risk Factors
• Socioeconomic Factors