Reduced Activity of Protein S in Plasma: A Risk Factor for Venous Thromboembolism in the Japanese Population.

Abstract

The quantitative assay of protein S can help in rapidly identifying carriers of abnormal protein S molecules through a simple procedure (by determining the total protein S mass, total protein S activity, and protein S-specific activity in blood), without genetic testing. To clarify the relationship between venous thromboembolism (VTE) and protein S-specific activity, and its role in the diagnosis of thrombosis in Japanese persons, the protein S-specific activity was measured and compared between patients with thrombosis and healthy individuals. The protein S-specific activity of each participant was calculated from the ratio of total protein S activity to total protein S antigen level. Plasma samples were collected from 133 healthy individuals, 57 patients with venous thrombosis, 118 patients with arterial thrombosis, and 185 non-thrombotic patients. The protein S-specific activity of one-third of the patients with VTE was below the line of Y = 0.85X (-2 S.D.). Most protein S activities in the plasma of non-thrombotic patients were near the Y = X line, as observed in healthy individuals. In conclusion, it was clearly shown that monitoring protein S activity and protein S-specific activity in blood is useful for predicting the onset and preventing venous thrombosis in at least the Japanese population.

• Authors: Xiuri Jin, Sachiko Kinoshita, Hiroyuki Kuma, Tomohide Tsuda, Tatsusada Yoshida, Dongchon Kang, Naotaka Hamasaki
• Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (Clin Appl Thromb Hemost) 2021 Jan-Dec Vol. 27 Pg. 10760296211033908 ISSN: 1938-2723 [Electronic] United States
• PMID: 34286618 (Publication Type: Journal Article)

Chemical References

• Protein S

Topics

• Female
• Humans
• Japan
• Male
• Protein S (metabolism)
• Risk Factors
• Venous Thromboembolism (etiology, physiopathology)