Abstract | INTRODUCTION: OBJECTIVE: This study was aimed to investigate the association of RF isotypes with systemic bone loss among patients with RA. METHODS: RF isotypes and ACPA were measured by enzyme-linked immunosorbent assay among 153 patients with RA. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry. RESULTS: Ninety-four (61.4%) patients had positive IgA RF, 89 (58.2%) had positive IgG RF, 109 (71.2%) had positive IgM RF, whereas 122 (80.3%) RA patients tested positive for ACPA. Compared to the IgA RF-negative patients, IgA RF-positive patients exhibited higher disease activity and had higher RF titers. Seven (4.6%) patients had low BMD at femoral neck, 12 (7.8%) at total femur, and 47 (30.7%) at lumbar spine. IgA RF was found to be associated with protection against low BMD at spine (OR = 0.47, 95% CI = 0.23-0.95, p = 0.034). This association was further confirmed in the multivariate regression analysis taking into account several potential confounding factors (OR = 0.21, 95% CI = 0.06-0.65, p = 0.039). No association between low BMD and the presence of IgG RF or IgM RF or ACPA was found. CONCLUSION:
IgA RF for the first time ever was shown to be associated with BMD preservation at spine in RA. Key points • IgA RF was associated with protection against low spinal BMD. • No association between low BMD and the presence of IgG RF or IgM RF was found.
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Authors | Rim Sghiri, Asma Boumiza, Hana Benhassine, Nejla Elamri, Zahid Shakoor, Foued Slama, Adel Almogren, Imed Harrabi, Jihen Sahli, Latifa Guaddah, Hala Zeglaoui, Elyes Bouajina |
Journal | Clinical rheumatology
(Clin Rheumatol)
Vol. 40
Issue 12
Pg. 4879-4887
(Dec 2021)
ISSN: 1434-9949 [Electronic] Germany |
PMID | 34282512
(Publication Type: Journal Article)
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Copyright | © 2021. International League of Associations for Rheumatology (ILAR). |
Chemical References |
- Anti-Citrullinated Protein Antibodies
- Immunoglobulin A
- Rheumatoid Factor
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Topics |
- Anti-Citrullinated Protein Antibodies
- Arthritis, Rheumatoid
- Bone Density
- Humans
- Immunoglobulin A
- Rheumatoid Factor
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