The main objective of this study was to assess the therapeutic activity of gum odina and
gelatin based biomimetic scaffold which was previously established as an excellent
wound dressing material. In the accelerated stability study, the changes in physicochemical properties were found to be negligible. The cytotoxicity studies were carried out in-vitro and the results showed that upto 90% of the cells remained viable in presence of the scaffold, confirming its biocompatibility. Moreover, results depicted the superior ability of the scaffold to promote cutaneous healing by increasing the rate of
wound contraction (about 98%), granulation formation,
collagen deposition and formation of an intact epidermis within 18 days. A satisfactory amount of
hydroxyproline (240.2 ± 6.67 μg/100 mg tissue) in scaffold treated groups at 21 days ensured the significant deposition of
collagen to re-epithelialization. Further it can be hypothesized that the controlled levels of
antioxidant enzymes (SOD, CAT) to diminish the oxidative stress in the wounded sites were due to the innate
antioxidant properties of both blank and
drug loaded scaffold. These results strongly indicated that the prepared scaffolds have strong potential for biomedical applications and it may serve as promising candidate for the next generation of
wound treatment systems.