PYCR, a key enzyme in proline metabolism, functions in tumorigenesis.

Abstract

Pyrroline-5-carboxylate reductase (PYCR), the last enzyme in proline synthesis that converts P5C into proline, was found promoting cancer growth and inhibiting apoptosis through multiple approaches, including regulating cell cycle and redox homeostasis, and promoting growth signaling pathways. Proline is abnormally up-regulated in multiple cancers and becomes one of the critical players in the reprogramming of cancer metabolism. As the last key enzymes in proline generation, PYCRs have been the subject of many investigations, and have been demonstrated to play an indispensable role in promoting tumorigenesis and cancer progression. In this article, we will thoroughly review the recent investigations on PYCRs in cancer development.

• Authors: Yutong Li, Juntao Bie, Chen Song, Minghui Liu, Jianyuan Luo
• Journal: Amino acids (Amino Acids) Vol. 53 Issue 12 Pg. 1841-1850 (Dec 2021) ISSN: 1438-2199 [Electronic] Austria
• PMID: 34273023 (Publication Type: Journal Article, Review)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

Chemical References

• Proline
• Pyrroline Carboxylate Reductases

Topics

• Animals
• Carcinogenesis (metabolism)
• Cell Cycle (physiology)
• Humans
• Neoplasms (metabolism)
• Oxidation-Reduction
• Proline (metabolism)
• Pyrroline Carboxylate Reductases (metabolism)