Abstract |
Photodynamic therapy ( PDT) is a promising alternative approach for effective cancer treatment that is associated with an antitumor immune response. However, immunosuppression of the tumor microenvironment limits the immune response induced by PDT. Stimulation and proliferation of T cells is a critical step for generating immune responses and depends on the efficient presentation of tumor antigens and co-stimulatory molecules by antigen-presenting cells (APCs). Here, biomimetic aggregation-induced emission (AIE) photosensitizers with antigen-presenting and hitchhiking abilities (DC@AIEdots) are developed by coating dendritic cell (DC) membranes on the nanoaggregates of the AIEgens. Notably, the inner AIE molecules can selectively accumulate in lipid droplets of tumor cells, and the outer cell membrane can facilitate the hitchhiking of DC@AIEdots onto the endogenous T cells and enhance the tumor delivery efficiency by about 1.6 times. Furthermore, DC@AIEdots can stimulate the in vivo proliferation and activation of T cells and trigger the immune system. The potential applications of therapeutic agents targeting lipid droplets for immunotherapy are indicated and a new hitchhiking approach for drug delivery is provided. Lastly, the study presents a photoactive and artificial antigen-presenting platform for effective T cell stimulation and cancer photodynamic immunotherapy.
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Authors | Xiuli Xu, Guanjun Deng, Zhihong Sun, Yuan Luo, Junkai Liu, Xinghua Yu, Yang Zhao, Ping Gong, Guozhen Liu, Pengfei Zhang, Fan Pan, Lintao Cai, Ben Zhong Tang |
Journal | Advanced materials (Deerfield Beach, Fla.)
(Adv Mater)
Vol. 33
Issue 33
Pg. e2102322
(Aug 2021)
ISSN: 1521-4095 [Electronic] Germany |
PMID | 34247428
(Publication Type: Journal Article)
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Copyright | © 2021 Wiley-VCH GmbH. |
Chemical References |
- 1,3-bis(dicyanomethylidene)indan
- Cytochromes
- Drug Carriers
- Hemoglobins
- Indans
- Melanins
- Photosensitizing Agents
- Reactive Oxygen Species
- 1,3-indandione
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Topics |
- Animals
- Biomimetic Materials
(chemistry)
- Cell Line, Tumor
- Cell Proliferation
- Cytochromes
(chemistry)
- Dendritic Cells
(chemistry)
- Drug Carriers
(chemistry)
- Female
- Hemoglobins
(chemistry)
- Humans
- Immunotherapy
(methods)
- Indans
(chemistry)
- Lipid Droplets
(chemistry)
- Melanins
(chemistry)
- Mice, Inbred BALB C
- Molecular Targeted Therapy
(methods)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(chemistry)
- Reactive Oxygen Species
(metabolism)
- T-Lymphocytes
- Tumor Microenvironment
(drug effects)
- Mice
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