Comparison of the clinical outcomes between NIMA-mismatched and NIPA-mismatched haploidentical hematopoietic stem cell transplantation for patients with hematological malignancies.

Abstract	The objective of this study was to compare clinical outcomes between noninherited maternal antigen (NIMA)-mismatched and noninherited paternal antigen (NIPA)-mismatched haploidentical hematopoietic stem cell transplantation (haplo-HSCT) among patients with hematological malignancies and perform a subgroup analysis. We retrospectively analyzed 378 patients with hematological malignancies who received haplo-HSCT from NIMA-mismatched (n = 201) and NIPA-mismatched (n = 177) donors between January 2012 and December 2017. The cumulative incidence of 100-d grades II-IV acute graft-versus-host disease (aGVHD) (19.2% vs. 32.8%, P = 0.003) was significantly lower in NIMA mismatch. Multivariate analysis showed that NIMA mismatch was associated with lower incidence of grades II-IV aGVHD and better overall survival (OS) and disease-free survival (DFS). According to the subgroup analysis, the clinical outcomes of older and/or female NIMA mismatches were comparable to those of younger and/or male NIPA mismatches with respect to grades II-IV aGVHD, chronic GVHD (cGVHD), nonrelapse mortality (NRM), relapse, DFS, and OS. In conclusion, this study confirmed the NIMA effect on aGVHD and demonstrated that NIMA mismatch was associated with better survival. In the NIMA mismatch context, donor age and sex did not seem to influence haplo-HSCT, which provides a basis for the selection of sibling donors.
Authors	Fei-Fei Tang, Xiang-Yu Zhao, Ming-Rui Huo, Ying-Jun Chang, Wei Han, Yu-Hong Chen, Chen-Hua Yan, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Yu Wang
Journal	Bone marrow transplantation (Bone Marrow Transplant) Vol. 56 Issue 11 Pg. 2723-2731 (11 2021) ISSN: 1476-5365 [Electronic] England
PMID	34239051 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
Topics	Female Graft vs Host Disease (etiology) Hematologic Neoplasms Hematopoietic Stem Cell Transplantation (methods) Humans Male Neoplasm Recurrence, Local Retrospective Studies Transplantation Conditioning (methods)

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