Osilodrostat in Cushing's disease: The risk of delayed adrenal insufficiency should be carefully monitored.

Abstract

Antisecretory data shows a highly effective and prolonged blockade of cortisol secretion with osilodrostat. The drawback is the occurrence of adrenal insufficiency (AI) in roughly a quarter of treated patients. In this short manuscript, we report three cases of atypical adrenal insufficiency with osilodrostat.

• Authors: Frederic Castinetti, Vincent Amodru, Thierry Brue
• Journal: Clinical endocrinology (Clin Endocrinol (Oxf)) Vol. 98 Issue 4 Pg. 629-630 (04 2023) ISSN: 1365-2265 [Electronic] England
• PMID: 34219265 (Publication Type: Letter)
• Copyright: © 2021 John Wiley & Sons Ltd.

Chemical References

• Osilodrostat
• Hydrocortisone
• Imidazoles

Topics

• Humans
• Pituitary ACTH Hypersecretion (complications)
• Hydrocortisone (therapeutic use)
• Adrenal Insufficiency
• Imidazoles