Uric acid played a role in the association between gender and deep vein thrombosis in patients with stroke.

Abstract

BACKGROUND AND AIMS:

Gender-specific differences were found in serum uric acid (SUA) levels and the risk of isolated distal deep vein thrombosis (IDDVT). This study aimed to explore the association among gender, SUA, and IDDVT in stroke patients.

METHODS AND RESULTS:

Finally, 3404 patients were recruited and divided into two groups: IDDVT (n = 1233) and Non-IDDVT (n = 2171) groups. Propensity score matching (PSM) was conducted to match the patients. Binary logistic regression was adopted to explore the association between SUA and IDDVT, with the SUA divided into quartiles. After PSM, 975 patients were included in each group. Non-IDDVT group had a larger proportion of male than IDDVT group (64.9% vs. 52.7%, p < 0.001). Moreover, males showed higher SUA levels than females (316.7 ± 102.1 vs. 261.8 ± 94.0 μmol/L, t = 12.1, p < 0.001). The highest quartile of SUA (≥346 μmol/L) showed a lower risk of IDDVT (OR = 0.629, p = 0.001), while the lowest quartile (≤225 μmol/L) showed a higher risk of IDDVT (OR = 1.361, p = 0.022).

CONCLUSION:

In patients with stroke, SUA played a protective role in IDDVT. Females had a higher risk of IDDVT, which may be owing to the lower SUA levels than males. In clinical practice, more attention should be paid to the risk of IDDVT in females, especially those with lower SUA levels.

• Authors: Wenwei Ren, Qiqi Huang, Kaili Fan, Jingjie Hu, Qianqian Cheng, Minjie Xu, Ruoting Xu, Yuntao Liu, Liping Wang, Siyan Chen, Wanli Zhang, Zhenguo Zhu, Chunxue Wu, Langlang Xue, Yanman Dai, Feifan Yan, Guiqian Huang, Jincai He
• Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD (Nutr Metab Cardiovasc Dis) Vol. 31 Issue 9 Pg. 2700-2706 (08 26 2021) ISSN: 1590-3729 [Electronic] Netherlands
• PMID: 34218986 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Uric Acid

Topics

• Aged
• Aged, 80 and over
• Biomarkers (blood)
• China (epidemiology)
• Cross-Sectional Studies
• Female
• Health Status Disparities
• Humans
• Male
• Middle Aged
• Protective Factors
• Risk Assessment
• Risk Factors
• Sex Factors
• Stroke (blood, diagnosis, epidemiology)
• Uric Acid (blood)
• Venous Thrombosis (blood, diagnostic imaging, epidemiology)