[Inhibitors of trypsin-like proteinases in human mixed saliva].

Abstract

Both BAEE esterase and antitryptic activities (ATA) were studied in mixed saliva of healthy persons and of patients with paradontosis. The ATA was measured in the saliva supernatant and in mixed saliva after thermo-acid treatment. The BAEE esterase activity was not found in 38% of healthy persons and in 41.2% of the patients with parodontosis; its mean values were lower in parodontosis as compared with normal state. The ATA could be measured in the saliva supernatant in Tris-HCl buffer; the activity was decreased in the saliva supernatant of the patients with parodontosis. Thermo-acid treatment increased the ATA values. In parodontosis ATA was increased 1.5-fold after the treatment, which appears to occur due to liberation of inhibitors from the complexes with proteins found in saliva and/or from leukocytes. In some cases the inhibitory properties of ATA were dissimilar in parodontosis after the thermo-acid treatment.

• Authors: T P Vavilova, N I Larionova, Iu A Petrovich
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1988 May-Jun Vol. 34 Issue 3 Pg. 74-8 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Ingibitory tripsinopodobnykh proteinaz smeshannoĭ sliuny cheloveka.
• PMID: 3420816 (Publication Type: English Abstract, Journal Article)

Chemical References

• Trypsin Inhibitors

Topics

• Humans
• Hydrolysis
• Kinetics
• Molecular Weight
• Saliva (enzymology)
• Trypsin Inhibitors (analysis)