Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes.

Abstract	Hyaluronic acid (HA) is one of the most used biopolymers in the development of drug delivery systems, due to its biocompatibility, biodegradability, non-immunogenicity and intrinsic-targeting properties. HA specifically binds to CD44; this property combined to the EPR effect could provide an option for reinforced active tumor targeting by nanocarriers, improving drug uptake by the cancer cells via the HA-CD44 receptor-mediated endocytosis pathway. Moreover, HA can be easily chemically modified to tailor its physico-chemical properties in view of specific applications. The derivatization with cholesterol confers to HA an amphiphilic character, and then the ability of anchoring to niosomes. HA-Chol was then used to coat Span® or Tween® niosomes providing them with an intrinsic targeting shell. The nanocarrier physico-chemical properties were analyzed in terms of hydrodynamic diameter, ζ-potential, and bilayer structural features to evaluate the difference between naked and HA-coated niosomes. Niosomes stability was evaluated over time and in bovine serum. Moreover, interaction properties of HA-coated nanovesicles with model membranes, namely liposomes, were studied, to obtain insights on their interaction behavior with biological membranes in future experiments. The obtained coated systems showed good chemical physical features and represent a good opportunity to carry out active targeting strategies.
Authors	Patrizia N Hanieh, Jacopo Forte, Chiara Di Meo, Maria Grazia Ammendolia, Elena Del Favero, Laura Cantù, Federica Rinaldi, Carlotta Marianecci, Maria Carafa
Journal	Molecules (Basel, Switzerland) (Molecules) Vol. 26 Issue 11 (Jun 05 2021) ISSN: 1420-3049 [Electronic] Switzerland
PMID	34198955 (Publication Type: Journal Article)
Chemical References	Hyaluronan Receptors Liposomes Hyaluronic Acid Cholesterol
Topics	Animals Biomimetic Materials (chemistry) Cattle Cell Membrane Cholesterol (chemistry) Drug Delivery Systems Drug Stability Hyaluronan Receptors (metabolism) Hyaluronic Acid (chemical synthesis, chemistry, pharmacology) Liposomes Nanostructures Particle Size Serum (chemistry)

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