| Abstract | Apathy, mood depression and extrapyramidal signs consisting of akinesia, amimia, gait apraxia, slight rigidity and tremor were induced in 10 patients by long-term treatment with flunarizine for trivial complaints. These symptoms suggest a mild antidopaminergic activity of flunarizine. Long-term administration of flunarizine should be avoided particularly in the elderly and in patients with extrapyramidal disorders. |
| Authors | A Lugaresi, P Montagna, R Gallassi, E Lugaresi
(Affiliation: Institute of Neurology, University of Bologna, Italy.)
|
| Journal | European neurology
(Eur Neurol)
Vol. 28
Issue 4
Pg. 208-11
( 1988)
ISSN: 0014-3022 SWITZERLAND |
| PMID | 3416889
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
|
| Topics |
- Aged
- Basal Ganglia Diseases
(chemically induced, complications, physiopathology)
- Depression
(chemically induced, complications, physiopathology)
- Female
- Flunarizine
(adverse effects)
- Humans
- Male
- Middle Aged
|
