[Morphological bases for the resistance of the intestines to the action of cholera toxoid].

Abstract

Effect of antigen (cholera toxoid) has been studied on distribution of specific antibody-containing plasma cells in the lamina propria of the mucous membrane of the guinea pig small and large intestine. Since it is known that experimental cholera is easily reproduced in these animals, amount of plasmocytes is determined after primary intraperitoneal and secondary intraduodenal immunization with cholera toxoid. At the primary immunization maximal increase in amount of plasmocytes is noted in the jejunum on the 70th day; at the secondary--on the 19th day. At the primary parenteral immunization of the animals with the antigen, the intensity of the immune response in the lamina propria of the mucous membrane increases. At the secondary immunization the local immunity is more manifested in comparison with the primary one.

• Authors: O P Kalugina
• Journal: Arkhiv anatomii, gistologii i embriologii (Arkh Anat Gistol Embriol) Vol. 94 Issue 3 Pg. 69-72 (Mar 1988) ISSN: 0004-1947 [Print] Russia (Federation)
• Vernacular Title: Morfologicheskie osnovy ustoĭchivosti kishechnika k deĭstviiu kholernogo toksoida.
• PMID: 3415485 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Bacterial
• Toxoids
• cholera toxoid
• Cholera Toxin

Topics

• Animals
• Antibodies, Bacterial (analysis)
• Antibody Specificity (drug effects)
• Cell Count (drug effects)
• Cholera Toxin
• Drug Resistance
• Guinea Pigs
• Immunization
• Intestinal Mucosa (drug effects, immunology)
• Intestine, Large (cytology, drug effects, immunology)
• Intestine, Small (cytology, drug effects, immunology)
• Male
• Plasma Cells (drug effects, immunology)
• Time Factors
• Toxoids (immunology)
• Vibrio cholerae (immunology)