Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment.

Abstract

Post translational modifications (PTM) such as phosphorylation are often correlated with tumorigenesis and malignancy in breast cancer. Herein, we report a PTM-assisted strategy as a simplified version of a personalized cancer vaccine for enhanced cancer immunotherapy. Titanium modified dendritic mesoporous silica nanoparticles (TiDMSN) are applied to assist the specific enrichment of phosphorylated tumor antigens released upon immunogenic cell death. This strategy significantly improved the tumor inhibition efficacy in a bilateral breast cancer model and the expansion of both CD8+ and CD4+ T cells in the distant tumor site. The nanotechnology based PTM-assisted strategy provides a simple and generalizable methodology for effective personalized cancer immunotherapy.

• Authors: Shevanuja Theivendran, Jie Tang, Chang Lei, Yannan Yang, Hao Song, Zhengying Gu, Yue Wang, Yang Yang, Lei Jin, Chengzhong Yu
• Journal: Chemical science (Chem Sci) Vol. 11 Issue 38 Pg. 10421-10430 (Sep 10 2020) ISSN: 2041-6520 [Print] England
• PMID: 34123182 (Publication Type: Journal Article)
• Copyright: This journal is © The Royal Society of Chemistry.