HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Tannins, salivary proline-rich proteins and oesophageal cancer.

Abstract
No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properties of tannins and extracts of tannin-rich plants have been demonstrated experimentally. It is proposed herein that salivary proline-rich proteins (PRPs) by binding ingested tannins protect the oesophagus from the carcinogenic effects of the latter. It is also possible that genetic variants of PRPs may influence the incidence of oesophageal cancer in different populations.
AuthorsT F Warner, E A Azen
JournalMedical hypotheses (Med Hypotheses) Vol. 26 Issue 2 Pg. 99-102 (Jun 1988) ISSN: 0306-9877 [Print] United States
PMID3412210 (Publication Type: Journal Article)
Chemical References
  • Peptides
  • Salivary Proteins and Peptides
  • Tannins
Topics
  • Esophageal Neoplasms (etiology, metabolism)
  • Feeding Behavior
  • Humans
  • Peptides (metabolism)
  • Plants, Edible
  • Proline-Rich Protein Domains
  • Salivary Proteins and Peptides (metabolism)
  • Tannins (adverse effects, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: