Abstract |
No single dietary factor or ingested substance has been implicated in the aetiology of oesophageal carcinoma especially in high-risk areas of the world. Although not well defined, there is heavy consumption of tannin-rich foods, particularly sorghum, by populations at high risk for carcinoma. The carcinogenic properties of tannins and extracts of tannin-rich plants have been demonstrated experimentally. It is proposed herein that salivary proline-rich proteins (PRPs) by binding ingested tannins protect the oesophagus from the carcinogenic effects of the latter. It is also possible that genetic variants of PRPs may influence the incidence of oesophageal cancer in different populations.
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Authors | T F Warner, E A Azen |
Journal | Medical hypotheses
(Med Hypotheses)
Vol. 26
Issue 2
Pg. 99-102
(Jun 1988)
ISSN: 0306-9877 [Print] United States |
PMID | 3412210
(Publication Type: Journal Article)
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Chemical References |
- Peptides
- Salivary Proteins and Peptides
- Tannins
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Topics |
- Esophageal Neoplasms
(etiology, metabolism)
- Feeding Behavior
- Humans
- Peptides
(metabolism)
- Plants, Edible
- Proline-Rich Protein Domains
- Salivary Proteins and Peptides
(metabolism)
- Tannins
(adverse effects, metabolism)
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