Biomimetic nanotherapy: core-shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma.

Abstract

BACKGROUND:

Non-Hodgkin's lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patients. Unfortunately, DOX is the main cytotoxic drug in R-CHOP and it can lead to adverse reactions. Therefore, it is particularly important to uncover new treatment options for NHL.

RESULTS:

In this study, a novel anti-tumor nanoparticle complex Nm@MSNs-DOX/SM was designed and constructed in this study. Mesoporous silica nanoparticles (MSNs) loaded with Doxorubicin (DOX) and anti-inflammatory drugs Shanzhiside methylester (SM) were used as the core of nanoparticles. Neutrophil membrane (Nm) can be coated with multiple nanonuclei as a shell. DOX combined with SM can enhance the anti-tumor effect, and induce apoptosis of lymphoma cells and inhibit the expression of inflammatory factors related to tumorigenesis depending on the regulation of Bcl-2 family-mediated mitochondrial pathways, such as TNF-α and IL-1β. Consequently, the tumor microenvironment (TME) was reshaped, and the anti-tumor effect of DOX was amplified. Besides, Nm has good biocompatibility and can enhance the EPR effect of Nm@MSNs-DOX/SM and increase the effect of active targeting tumors.

CONCLUSIONS:

This suggests that the Nm-modified drug delivery system Nm@MSNs-DOX/SM is a promising targeted chemotherapy and anti-inflammatory therapy nanocomplex, and may be employed as a specific and efficient anti-Lymphoma therapy.

• Authors: Qiangqiang Zhao, Duanfeng Jiang, Xiaoying Sun, Qiuyu Mo, Shaobin Chen, Wansong Chen, Rong Gui, Xianjun Ma
• Journal: Journal of nanobiotechnology (J Nanobiotechnology) Vol. 19 Issue 1 Pg. 179 (Jun 13 2021) ISSN: 1477-3155 [Electronic] England
• PMID: 34120620 (Publication Type: Journal Article)

Chemical References

• Drug Carriers
• Silicon Dioxide
• Doxorubicin

Topics

• Animals
• Apoptosis (drug effects)
• Biomimetics (methods)
• Disease Models, Animal
• Doxorubicin (administration & dosage)
• Drug Carriers (pharmacology)
• Drug Delivery Systems (methods)
• Humans
• Lymphoma (drug therapy)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Nanoparticles (chemistry)
• Neoplasms (drug therapy)
• Neutrophils (drug effects)
• Particle Size
• Silicon Dioxide (pharmacology)
• Tumor Microenvironment (drug effects)
• Xenograft Model Antitumor Assays